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AN141-RevA0-Quantitative_Nanomechanical_Measurements_on_Live_Cells_with_PeakForce_QNM-Datasheet.pdf
We are pleased to share with you the latest Application Note #141 in Biological AFM entitled “Toward Quantitative Nanomechanical Measurements on Live Cells with PeakForce QNM”.Biological samples, such as live cells, tend to have very low moduli and must often be studied in a fluid environment. As such, to date reliable PeakForce QNM studies have been somewhat challenging to perform. This document describes Bruker’s latest developments in obtaining true quantitative measurements of the nanomechanical properties of both live mammalian and bacteria cells as well as bio-mimicking agarose gel substrates. Data is also presented that shows how PeakForce QNM is already helping to advance our customers’ research to conduct important studies on cancer cells and living plant cells. The authors of this Application Note are Bede Pittenger, Andrea Slade, and Alex Berquand of Bruker Nano Inc. together with collaborators Pascale Milani, Arezki Boudaoud and Olivier Hamant of Ecole Normale Superieure de Lyon, France.Mammalian cell studies were conducted in the Bruker Santa Barbara Laboratories in collaboration with Prof. Manfred Radmacher, as part of the Biological Advisory Team (BAT) Project.