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Drebrin Induced Remodeling of F-Actin with Subnanometer Resolution

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posted by Shivani Sharma
Mon, Dec 19 2011
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Drebrin Induced Remodeling of F-Actin with Subnanometer Resolution

Atomic Force Microscopy Reveals Drebrin Induced Remodeling of F-Actin with Subnanometer Resolution
Shivani Sharma, Elena E. Grintsevich, Martin L. Phillips, Emil Reisler, and James K. Gimzewski
Nano Lett., 2011, 11 (2), pp 825–827
Publication Date (Web): December 22, 2010 (Letter)

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Shivani Sharma wrote re: Drebrin Induced Remodeling of F-Actin with Subnanometer Resolution
on Mon, Dec 19 2011 7:07 PM

We show by high-resolution atomic force microscopy analysis that drebrin A (a major neuronal actin binding protein) induced F-actin structural and mechanical remodeling involves significant changes in helical twist and filament stiffness (+55% persistence length). These results provide evidence of a unique mechanical role of drebrin in the dendrites, contribute to current molecular-level understanding of the properties of the neuronal cytoskeleton, and reflect the role of biomechanics at the nanoscale, to modulate nanofilament-structure assemblies such as F-actin

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