The Nanoscale World
Media » Community Media » Publications » Drebrin Induced Remodeling of F-Actin with Subnanometer Resolution

Forums           

Bruker Media

Community Media

Bruker AFM Probes

SPM Digest

Application Notes

NanoTheater

Website

中文

Brochures & Datasheets

Publications

Probes Catalog

Events

Manuals & Documentation

Presentations

Guide to AFM Modes

News

Journal Club

Webinars & Video

Nanovations

Other

 

 

Drebrin Induced Remodeling of F-Actin with Subnanometer Resolution

Previous | Next | View all files | View Slideshow
posted by Shivani Sharma
Mon, Dec 19 2011
Downloads: 6
Views: 2,714
Drebrin Induced Remodeling of F-Actin with Subnanometer Resolution

Atomic Force Microscopy Reveals Drebrin Induced Remodeling of F-Actin with Subnanometer Resolution
Shivani Sharma, Elena E. Grintsevich, Martin L. Phillips, Emil Reisler, and James K. Gimzewski
Nano Lett., 2011, 11 (2), pp 825–827
Publication Date (Web): December 22, 2010 (Letter)

Comments

Shivani Sharma wrote re: Drebrin Induced Remodeling of F-Actin with Subnanometer Resolution
on Mon, Dec 19 2011 7:07 PM

We show by high-resolution atomic force microscopy analysis that drebrin A (a major neuronal actin binding protein) induced F-actin structural and mechanical remodeling involves significant changes in helical twist and filament stiffness (+55% persistence length). These results provide evidence of a unique mechanical role of drebrin in the dendrites, contribute to current molecular-level understanding of the properties of the neuronal cytoskeleton, and reflect the role of biomechanics at the nanoscale, to modulate nanofilament-structure assemblies such as F-actin

Copyright (c) 2011 Bruker Instruments