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Atomic force microscopy (AFM) has opened exciting new avenues in microbiology and biophysics for probing microbial cells. The unprecedented capabilities of AFM can be summarized as follows: i) imaging surface topography with nanometer lateral resolution and under physiological conditions; ii) measuring local physical properties such as adhesion forces
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AFM has contributed to ground-breaking research in the investigation of DNA, proteins, and cells in biological studies; structure and component distribution in polymer science; piconewton force interactions and surfactant behavior in colloid science; and physical/ mechanical properties and fabrication variables in the material sciences. Pharmaceutical
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Because microbial surfaces are in direct contact with the external environment, they are vital to organisms. Microbial surfaces play key roles in determining cellular shape and growth, enabling organisms to resist turgor pressure, acting as molecular sieves, and mediating molecular recognition and cellular interactions. Therefore, studying the structure
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Normal 0 false false false MicrosoftInternetExplorer4 Current antibacterial drugs might become ineffective in the near future due to a phenomenon called pharmacoresistance. This refers to the ability of microorganisms to withstand bacteriocidal (cell killing) or bacteriostatic (inhibition of growth) effects caused by antibiotics1. Bacteria are known
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The combination of optical with scanning probe microscopy techniques has become a powerful tool for sensing biological events on nanoscale. This combination will significantly contribute to providing new insights to the fields of biosensors, pharmacology, drug discovery, cancer research or nanomedicine over the next few years. In addition to its high