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Brochure describing Bruker's BioScope Catalyst Perfusing Stage Incubator accessory.
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Atomic force microscopy (AFM) has opened exciting new avenues in microbiology and biophysics for probing microbial cells. The unprecedented capabilities of AFM can be summarized as follows: i) imaging surface topography with nanometer lateral resolution and under physiological conditions; ii) measuring local physical properties such as adhesion forces
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AFM has contributed to ground-breaking research in the investigation of DNA, proteins, and cells in biological studies; structure and component distribution in polymer science; piconewton force interactions and surfactant behavior in colloid science; and physical/ mechanical properties and fabrication variables in the material sciences. Pharmaceutical
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In the following study, we demonstrate the power of combining atomic force microscopy AFM and fluorescence microscopy techniques to probe real-time, in-situ effects of two highly specific drugs that are able to disrupt different cytoskeleton networks inside living cells. Using Veeco Multiple Image Registration Overlay (MIRO) software and the new Bioscope
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There is great interest in unraveling action mechanisms of key enzymes in biological processes. In many cases, insight on such molecular events can be derived from conventional biophysical analyses of isolated enzymes and their substrates or protein partners. For example, members of the matrix metalloproteinases (MMP) family have been implicated in