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Cell biology has seen a surge in mechanobiology-related research directed toward understanding how cells exert and respond to forces. Forces are increasingly recognized as major regulators of cell structure and function. The mechanical properties of cells are essential to the mechanisms by which cells sense forces, transmit them to the cell interior
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Bruker’s BioScope Resolve™ BioAFM features the highest resolution atomic force microscopy imaging and most complete cell mechanics capabilities available for use with an inverted optical microscope. BioScope Resolve incorporates Bruker’s exclusive PeakForce Tapping® technology to enable researchers to achieve the highest resolution
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Brochure describing Bruker's BioScope Catalyst Perfusing Stage Incubator accessory.
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The Veeco Bioscope Catalyst - AFM with Inverted Optical Microscope Mickael Febvre from Veeco takes us for a tour of the Bioscope Catalyst, which is an atomic force microscope (AFM) with an inverted optical microscope. The system is suited to biological applications. Mickael also shows us through the software package and demonstrates a new detection
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Mechanical properties of cells are determined by the dynamic behavior of the cytoskeleton and physical interactions with the environment. The cytoskeleton, composed of actin filaments, intermediate filaments, and microtubules, is vital for numerous key cellular processes, such as cell division, vesicle trafficking, cell contraction, cell motility, and
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Atomic force microscopy (AFM) has opened exciting new avenues in microbiology and biophysics for probing microbial cells. The unprecedented capabilities of AFM can be summarized as follows: i) imaging surface topography with nanometer lateral resolution and under physiological conditions; ii) measuring local physical properties such as adhesion forces
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AFM has contributed to ground-breaking research in the investigation of DNA, proteins, and cells in biological studies; structure and component distribution in polymer science; piconewton force interactions and surfactant behavior in colloid science; and physical/ mechanical properties and fabrication variables in the material sciences. Pharmaceutical
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Microscopic evaluation is important for the design and evaluation of a pharmaceutical product after the steps in the drug formulation process. Since atomic force microscopy (AFM) provides the ability to directly investigate surface structure at nanometer-to-subangstrom resolution in ambient and liquid environments, it has been applied to a wide range
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The atomic force microscope (AFM) offers extraordinarily high resolution in force measurement applications, routinely yielding useful data down to the thermal noise floor of the cantilever, typically about 10pN. This along with the ease with which it is applied to many biological systems has made it a popular tool for studying such things as the specific
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The best research instruments not only acquire the intended data, but actually increase productivity. Bruker’s BioScope Catalyst Atomic Force Microscope (AFM) accelerates innovative research by reducing the time and effort needed to combine the proven techniques of light microscopy with the unique benefits of atomic force microscopy.