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Mechanical properties of cells are determined by the dynamic behavior of the cytoskeleton and physical interactions with the environment. The cytoskeleton, composed of actin filaments, intermediate filaments, and microtubules, is vital for numerous key cellular processes, such as cell division, vesicle trafficking, cell contraction, cell motility, and
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HarmoniX Nanoscale Material Property Mapping mode with fluorescence microscopy is used to probe the surface characteristics of tissues isolated from the wheat grain. The resulting data provides new insights into this essential ingredient in human nutrition.
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The new MIRO 2.0 (Microscope Image Registration and Overlay) software completes the compromise-free integration of optical and atomic force microscopy (AFM) by providing the tools necessary to control the combined optical/AFM Bioscope™ Catalyst TM system and analyze the resulting data. MIRO 2.0 allows AFM and optical data to be overlaid on the
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The best research instruments not only acquire the intended data, but actually increase productivity. Bruker’s BioScope Catalyst Atomic Force Microscope (AFM) accelerates innovative research by reducing the time and effort needed to combine the proven techniques of light microscopy with the unique benefits of atomic force microscopy.
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In the following study, we demonstrate the power of combining atomic force microscopy AFM and fluorescence microscopy techniques to probe real-time, in-situ effects of two highly specific drugs that are able to disrupt different cytoskeleton networks inside living cells. Using Veeco Multiple Image Registration Overlay (MIRO) software and the new Bioscope
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There is great interest in unraveling action mechanisms of key enzymes in biological processes. In many cases, insight on such molecular events can be derived from conventional biophysical analyses of isolated enzymes and their substrates or protein partners. For example, members of the matrix metalloproteinases (MMP) family have been implicated in