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The atomic force microscope (AFM) offers extraordinarily high resolution in force measurement applications, routinely yielding useful data down to the thermal noise floor of the cantilever, typically about 10pN. This along with the ease with which it is applied to many biological systems has made it a popular tool for studying such things as the specific
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The best research instruments not only acquire the intended data, but actually increase productivity. Bruker’s BioScope Catalyst Atomic Force Microscope (AFM) accelerates innovative research by reducing the time and effort needed to combine the proven techniques of light microscopy with the unique benefits of atomic force microscopy.
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In the following study, we demonstrate the power of combining atomic force microscopy AFM and fluorescence microscopy techniques to probe real-time, in-situ effects of two highly specific drugs that are able to disrupt different cytoskeleton networks inside living cells. Using Veeco Multiple Image Registration Overlay (MIRO) software and the new Bioscope
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There is great interest in unraveling action mechanisms of key enzymes in biological processes. In many cases, insight on such molecular events can be derived from conventional biophysical analyses of isolated enzymes and their substrates or protein partners. For example, members of the matrix metalloproteinases (MMP) family have been implicated in