-
Cell biology has seen a surge in mechanobiology-related research directed toward understanding how cells exert and respond to forces. Forces are increasingly recognized as major regulators of cell structure and function. The mechanical properties of cells are essential to the mechanisms by which cells sense forces, transmit them to the cell interior
-
After two years of work, the book I'm editing is out now: "Life at the Nanoscale: Atomic Force Microscopy of Live Cells". Life at the Nanoscale provides a state-of-the-art overview about how atomic force microscopy (AFM) can be used to image living cells, to probe their attachment to substrates or to other cells, to measure their mechanical
-
AN135-Rev A0-Quantitative-Imaging-Living-Biological-Samples-PeakForceQNM-(HiRes).pdf This article summarizes work that has conducted over the past year on living (and thus soft) samples by using Peak Force QNM. It focuses on silicified organisms, bacteria, and eukaryiotic cells. The Note also proposes a range of probes that can be used to address these
-
It is now well established that measuring ex vivo the mechanical properties of living cells can be a good indicator of the health of the organism from which they were extracted. Atomic force microscopy (AFM) is a powerful investigation and diagnostic tool, especially in force mode. Nevertheless, force spectroscopy suffers from several limitations, including
-
Brochure describing Bruker's BioScope Catalyst Perfusing Stage Incubator accessory.
-
Veeco recently released a new Perfusing Stage Incubator accessory for the BioScope Catalyst. It enables long term maintenance of cells in situ on the BioScope Catalyst. Please see the article just published in Microscopy and Analysis for more details ( Link here ). Abstract Atomic force microscopy has proven itself to be a valuable technique for cell
-
Alexandre Berquand, Applications Scientist at Veeco, in partnership with the Pr. Petra Kioshis Group at the Hochschule Mannheim, have published a paper in the March issue of Microscopy Today titled: Analysis of Cytoskeleton-Destabilizing Agents by Optimized Optical Navigation and AFM Force Measurements. (See Link above or Media Section) This paper is
-
Mechanical properties of cells are determined by the dynamic behavior of the cytoskeleton and physical interactions with the environment. The cytoskeleton, composed of actin filaments, intermediate filaments, and microtubules, is vital for numerous key cellular processes, such as cell division, vesicle trafficking, cell contraction, cell motility, and
-
Why is it difficulty to image live cell with PeakForce QNM if it can control the image force at a very low level?
-
Atomic force microscopy (AFM) has opened exciting new avenues in microbiology and biophysics for probing microbial cells. The unprecedented capabilities of AFM can be summarized as follows: i) imaging surface topography with nanometer lateral resolution and under physiological conditions; ii) measuring local physical properties such as adhesion forces