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Dear Leon, From your message is probably missing the most important information, namely what kind of samples you are working on. Since you are using a Catalyst facility I guess you may rather be working on cell samples. It comes out that for cells, there can be some proteins floating around on top of the cells that will be acting as brushes and may
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Hi Ester, As the definition of the Poisson’s ration is quite straight forward in the case of an isotropic bulk material, in the case of biological material (I guess cells) its definition is way more complicated if not impossible to be made. Indeed, mechanically looking, a cell is a cross linked water gel caged within an elastic membrane with a
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Dear Naphtali, I was gluing colloidal probes cantilevers for several years and put a small description on how this was made in the following paper (P. Carl, S. Hermann, Elasticity measurement of living cells with an atomic force microscope: data acquisition and processing, Pflugers Arch - Eur J Physiol. 457, 551–559 (2008)). In this paper, you
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Dear Steve, It seems to me, but I may be wrong, that the fact that a paper has once been published in a high quality and thorough peer review journal like Nature with a stiffness in Pa, doesn’t mean that stiffness and Young’s modulus are physical quantities that should have the same meaning (and/or unit). Also, you have completely missed
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Hi Steven, I’m doing fine thank you and enjoy right now the pleasure of having become again father a couple of months ago. As you probably know, I have already invested more than 10 years in the development of tools and methods in order to improve and make easier the analysis of force spectroscopy data. Thus I get quite disturbed when I see mistakes
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Hi Stephen, How are you doing? I have got a fast look on your attached picture and have to admit that I have quite some problems with it. So first, wasn't the drawn curve rather obtained from a regular force distance acquisition and not from a PeakForce (= Pulsed Force Mode) acquisition, since in this case you would still see some remaining oscillations
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Hi Gerard, Would, given the samples you want to study, a nano-indenter not be a more advised tool than an AFM? Best regards, Philippe