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Cell biology has seen a surge in mechanobiology-related research directed toward understanding how cells exert and respond to forces. Forces are increasingly recognized as major regulators of cell structure and function. The mechanical properties of cells are essential to the mechanisms by which cells...
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Brochure describing Bruker's BioScope Catalyst Perfusing Stage Incubator accessory.
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Veeco recently released a new Perfusing Stage Incubator accessory for the BioScope Catalyst. It enables long term maintenance of cells in situ on the BioScope Catalyst. Please see the article just published in Microscopy and Analysis for more details ( Link here ). Abstract Atomic force microscopy has...
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Mechanical properties of cells are determined by the dynamic behavior of the cytoskeleton and physical interactions with the environment. The cytoskeleton, composed of actin filaments, intermediate filaments, and microtubules, is vital for numerous key cellular processes, such as cell division, vesicle...
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Atomic force microscopy (AFM) has opened exciting new avenues in microbiology and biophysics for probing microbial cells. The unprecedented capabilities of AFM can be summarized as follows: i) imaging surface topography with nanometer lateral resolution and under physiological conditions; ii) measuring...
Posted to
Application Notes
by
BrukerApplications
on Wed, Jan 6 2010
Filed under: Cells, BioScope, Catalyst, BioScope II, Fluid Imaging, Bacteria, Cell Identification, Application Note
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AFM has contributed to ground-breaking research in the investigation of DNA, proteins, and cells in biological studies; structure and component distribution in polymer science; piconewton force interactions and surfactant behavior in colloid science; and physical/ mechanical properties and fabrication...
Posted to
Application Notes
by
BrukerApplications
on Wed, Jan 6 2010
Filed under: Drugs, Cells, BioScope, Catalyst, BioScope II, Bacteria, Pharmacology, Cell Identification, Application Note
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In the following study, we demonstrate the power of combining atomic force microscopy AFM and fluorescence microscopy techniques to probe real-time, in-situ effects of two highly specific drugs that are able to disrupt different cytoskeleton networks inside living cells. Using Veeco Multiple Image Registration...
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There is great interest in unraveling action mechanisms of key enzymes in biological processes. In many cases, insight on such molecular events can be derived from conventional biophysical analyses of isolated enzymes and their substrates or protein partners. For example, members of the matrix metalloproteinases...